Enzymatic enantiomeric resolution of phenylethylamines structurally related to amphetamine

Enzymatic enantiomeric resolution of phenylethylamines structurally related to amphetamine.

Both enantiomers of several phenylethylamines, structurally related to amphetamine, have been prepared in good yields and excellent enantiomeric purity by enzymatic kinetic resolution using CAL-B and ethyl methoxyacetate as the acyl donor. In the case of the 4-hydroxyderivative of amphetamine (compound 4i), the S enantiomer racemized possibly in a dynamic kinetic resolution (DKR) under the enzy...

Enantiomeric scaffolding of α-tetralone and related scaffolds by EKR (enzymatic kinetic resolution) and stereoselective ketoreduction with ketoreductases.

Stereochemically pure compounds containing an all carbon quaternary stereocenter based on 1-tetralone, 1-indanone and 4-chromanone scaffolds have been synthesized by employing Lipase PS (Burkholderia cepacia) catalyzed kinetic resolution. These scaffolds are further functionalized by microbial ketoreductase enzymes (Geotrichum candidum, Candida parapsilosis and Aspergillus niger) to access ster...

The Enzymatic Deamination of Amphetamine

A previous st,udy on the metabolism of amphetamine (1-phenyl-2-aminopropane), widely used as a stimulant of the central nervous system, showed that its major route of biotransformation in the rat and dog involved hydroxylation of the aromatic ring. In the rabbit, however, the compound was not hydroxylated, but was found to be transformed in another manner (2). The present report describes an en...

The enzymatic deamination of amphetamine (benzedrine).

EMDee: an enzymatic method for determining enantiomeric excess.

The techniques of combinatorial chemistry have recently been applied to the discovery of new asymmetric catalysts for a variety of organic transformations.1 These techniques are useful for increasing the efficiency by which chiral ligands for metal catalysts are discovered since the design of these ligands is largely an empirical process, and there are currently no simple rules for reliably pro...